CHIP Chaperones Wild Type p53 Tumor Suppressor Protein
نویسندگان
چکیده
منابع مشابه
Hsp90 chaperones wild-type p53 tumor suppressor protein.
Immortalized human fibroblasts were used to investigate the putative interactions of the Hsp90 molecular chaperone with the wild-type p53 tumor suppressor protein. We show that geldanamycin or radicicol, specific inhibitors of Hsp90, diminish specific wild-type p53 binding to the p21 promoter sequence. Consequently, these inhibitors decrease p21 mRNA levels, which lead to a reduction in cellula...
متن کاملInactivation of wild-type p53 tumor suppressor by electrophilic prostaglandins.
The electrophilic eicosanoids prostaglandins A(1) or A(2) impaired p53-dependent transcription of endogenous genes and exogenous p53-luciferase reporter plasmids in RKO and HCT 116 colon cancer cells. Cellular accumulation of genetically wild-type, but transcriptionally silent p53 varied as a function of exposure time and concentration of prostaglandins A(1) and A(2). Prostaglandins A(1) and A(...
متن کاملModifications of Wild-Type p53 Tumor Suppressor Protein Nitric Oxide Induces Conformational and Functional
Incubation in vitroof recombinant wild-type murine p53 protein with S-nitroso-N-acetyl-DL-penidillamine [a nitric oxide (NO)-releasing corn pound] has resulted in a change of p53 conformation and also in a significant decrease of its specific DNA binding activity. Similarly, upon treatment with S-altroso-N-acetyl.DL-pealcillamine(2—5 mM)or S-nitroso glutathione (1-2 mM), human breast cancer c...
متن کاملNitric oxide induces conformational and functional modifications of wild-type p53 tumor suppressor protein.
Incubation in vitro of recombinant wild-type murine p53 protein with S-nitroso-N-acetyl-DL-penicillamine [a nitric oxide (NO)-releasing compound] has resulted in a change of p53 conformation and also in a significant decrease of its specific DNA binding activity. Similarly, upon treatment with S-nitroso-N-acetyl-DL-penicillamine (2-5 mM) or S-nitroso-glutathione (1-2 mM), human breast cancer ce...
متن کاملChaperoning of mutant p53 protein by wild-type p53 protein causes hypoxic tumor regression.
Mutant (Mt) p53 abrogates tumor suppression functions of wild-type (WT) p53 through mutant-specific, gain-of-function effects, and patients bearing Mt p53 are chemoresistant. The dominant negative effect of p53 mutants results from their aggregation propensity which causes co-aggregation of WT p53. We explored the mechanism of p53 inactivation in hypoxia and hypothesized whether WT p53 could re...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2007
ISSN: 0021-9258
DOI: 10.1074/jbc.m703698200